It is used as a program database file type that many applications use such as MS Visual Studio, Pegasus, etc. However, in this format, .pdb files usually cannot be opened by just any application other than the application installed with it. 

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This file extension is used as a Palm Desktop Database File wherein it is also used by Palm-based PDA devices. These files contain variety of information. They can be spreadsheets, databases, images, etc. 

The .pdb files are files in the Protein Data Bank File format; a format used when studying structures of protein which is why these files are mostly used by the Research Collaboratory for Structural Bioinformatics.

The .pdb file extension is used as PowerDesigner Database Backup File used by PowerDesigner database wherein these .pdb files refer to data that this database saves as well as they also contain other file references.

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